Combined determination of n–myc oncogene amplification and dna ploidy in neuroblastoma complementary prognostic indicators
نویسندگان
چکیده
منابع مشابه
Retrospective study of prognostic value of DNA ploidy and proliferative activity in neuroblastoma.
AIM To assess the prognostic value of age and stage at diagnosis, site of primary tumour, cell ploidy and N-myc copy number in children with neuroblastoma. METHODS Flow cytometry was used to determine the cellular DNA content of paraffin wax embedded archival material from 69 cases of neuroblastoma and was successful in 52. RESULTS The age, stage, and survival distribution of the sampled ca...
متن کاملCombined analysis of DNA ploidy index and N-myc genomic content in neuroblastoma.
The aim of the study was to assess, in a group of nonselected patients with neuroblastoma, the prognostic value of both N-myc gene amplification and DNA ploidy index, taking into account potential confounding factors such as age and stage. Of 59 patients studied, 23 were younger than 1 year at diagnosis, 31 presented with stage IV, 10 with stage III, 5 with stage II, 8 with stage I, and 4 with ...
متن کاملChronic radiation exposure of neuroblastoma cells reduces nMYC copy number
Neuroblastoma accounts for >15% of cancer-associated mortalities of children in the USA. Despite aggressive treatment regimens, the long-term survival for these children remains <40%. The identification of v-Myc avian myelocytomatosis viral oncogene neuroblastoma-derived homolog (nMYC) gene amplification during diagnosis is associated with poor prognosis in neuroblastoma. There are limited stud...
متن کاملTelomerase expression as complementary prognostic factor in neuroblastoma.
BACKGROUND Neuroblastoma (NB) is an aggressive tumor of childhood with a highly heterogeneous course. Identification of standard prognostic factors has several limitations. Hence, there is an increasing demand to identify new prognostic factors and tools that help in risk stratification of patients for proper treatment. OBJECTIVE To assess the prognostic and predictive impact of quantitative ...
متن کامل[The prognostic significance of DNA ploidy in laryngeal cancers].
OBJECTIVES We assessed the relationship between DNA ploidy and histopathologic parameters and its effect on prognosis in patients with squamous cell carcinoma of the larynx. PATIENTS AND METHODS Surgical sections of 44 patients who were treated for squamous cell carcinoma of the larynx were studied. Image cytometry measurements were performed on nuclear suspensions derived from paraffin-embed...
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ژورنال
عنوان ژورنال: Cancer
سال: 1993
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19931101)72:9<2763::aid-cncr2820720938>3.0.co;2-x